Glyceroneogenesis and the triglyceride/fatty acid cycle.
نویسندگان
چکیده
From the ‡Department of Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel, the §Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4935, the ¶Schwartz Center for Metabolism and Nutrition, MetroHealth Center, Cleveland, Ohio 44109, and the Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544
منابع مشابه
Thiazolidinediones block fatty acid release by inducing glyceroneogenesis in fat cells.
Thiazolidinediones are used to treat type 2 diabetes mellitus because they decrease plasma glucose, insulin, triglyceride, and fatty acid levels. Thiazolidinediones are agonists for peroxisome proliferator-activated receptor gamma, a nuclear receptor that is highly expressed in fat tissue. We identify glyceroneogenesis as a target of thiazolidinediones in cultured adipocytes and fat tissues of ...
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Fatty acid (FA) release from white adipose tissue (WAT) is the result of the balance between triglyceride breakdown and FA re-esterification. The latter relies on the induction of cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C), the key enzyme for glyceroneogenesis. We previously demonstrated that long-term (18 h) leptin treatment of rat epididymal WAT explants reduced glyceroneogenesis t...
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BACKGROUND The metabolic function of PEPCK-C is not fully understood; deletion of the gene for the enzyme in mice provides an opportunity to fully assess its function. METHODS The gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) (PEPCK-C) was deleted in mice by homologous recombination (PEPCK-C-/- mice) and the metabolic consequences assessed. RESULTS PEP...
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The synthesis and breakdown of triglycerides in adipose tissue and muscle is a crucial element of energy metabolism because it ensures that adequate fuel is available during starvation. Triglyceride turnover determines the availability of fatty acids for utilization by mammalian tissues, and any dysfunction in this process can lead to alterations in glucose metabolism, insulin resistance and ty...
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Adipose tissue glyceroneogenesis generates glycerol 3-phosphate, which could be used for fatty acid esterification during starvation. To determine whether increased glyceroneogenesis leads to increased fat mass and to explore the role of obesity in the development of insulin resistance, we overexpressed PEPCK, a regulatory enzyme of glyceroneogenesis in adipose tissue. Transgenic mice showed a ...
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ورودعنوان ژورنال:
- The Journal of biological chemistry
دوره 278 33 شماره
صفحات -
تاریخ انتشار 2003